An Incredible Love Affair

Riddle: The following is one of those boy-gets-girl, boy-loses-girl, boy-gets-girl romantic stories. This famous couple first met back in 1961 while doing a TV commercial together. The pair instantly became boyfriend and girlfriend and continued dating until Valentine's Day of 2004, when the girl finally broke off the relationship. Rumor had it at the time that the girl (now a grown woman) wanted to get married, but the boy (now a grown man) was afraid of commitment, even after dating the woman for 43 years. However, the man had some plastic surgery done two years later (reportedly to impress the woman), and the couple got back together in 2011. It is incredible to imagine, but since this duo first got together, the man has had 40 different occupations, while the woman has had at least 200 separate careers -- even running for President of the United States at one point! Who are these two lovebirds who have had such a lengthy and interesting relationship?